This act provides $40.1 billion in FY2022 emergency supplemental appropriations for activities to respond to Russia's invasion of Ukraine. The act provides appropriations to several federal departments and agencies, including the Department of Justice, the Department of Defense, the Nuclear Regulatory Commission, the Department of Health and Human Services, the Department of State, the U.S. Agency for International Development, the Department of Agriculture, and the Department of the Treasury. Among other things, the act provides appropriations for defense equipment, migration and refugee assistance, regulatory and technical support regarding nuclear power issues, emergency food assistance, economic assistance, and seizures of property related to the invasion.